USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

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Searching in 'USC-OGP 2-DE database' for entry matching: P48643 USC-OGP 2-DE database:  P48643 P48643 General information about the entry View entry in simple text format Entry name TCPE_HUMAN Primary accession number P48643 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=T-complex protein 1 subunit epsilon; Short=TCP-1-epsilon; AltName: Full=CCT-epsilon;. Gene name Name=CCT5 Synonyms=CCTE, KIAA0098 Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein PLATELET_4-7 {PLATELET 4-7} Homo sapiens (Human)   map experimental info   PLATELET_4-7 MAP LOCATIONS: SPOT OGP-0334: pI=5.28; Mw=61464 SPOT OGP-0335: pI=5.34; Mw=61275 PLATELET_5-6 {PLATELET 5-6} Homo sapiens (Human)   map experimental info   PLATELET_5-6 MAP LOCATIONS: SPOT OGP-0643: pI=5.26; Mw=62162 SPOT OGP-0646: pI=5.31; Mw=61438 UVEAL_MELANOMA_3-10 {UVEAL MELANOMA 3-10} Homo sapiens (Human)   map experimental info   UVEAL_MELANOMA_3-10 MAP LOCATIONS: SPOT OGP-1141: pI=5.49; Mw=61289 Cross-references UniProtKB/Swiss-Prot P48643; TCPE_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name TCPE_HUMAN Primary accession number P48643 Secondary accession number(s) A8JZY8 A8K2X8 B4DYD8 Sequence was last modified on  February 1, 1996 (version 1) Annotations were last modified on  March 15, 2017 (version 173) Name and origin of the protein Description RecName: Full=T-complex protein 1 subunit epsilon; Short=TCP-1-epsilon; AltName: Full=CCT-epsilon; Gene name Name=CCT5 Synonyms=CCTE, KIAA0098 Encoded on Name=CCT5; Synonyms=CCTE, KIAA0098 Keywords Acetylation; Alternative splicing; ATP-binding; Chaperone; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Disease mutation; Neuropathy; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL D43950; BAA07894.2; ALT_INIT; mRNA EMBL AK289353; BAF82042.1; -; mRNA EMBL AK290393; BAF83082.1; -; mRNA EMBL AK302383; BAG63700.1; -; mRNA EMBL AC012640; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL CH471102; EAX08072.1; -; Genomic_DNA EMBL BC006543; AAH06543.1; -; mRNA EMBL BC035499; AAH35499.1; -; mRNA CCDS CCDS3877.1; -. [P48643-1]; . CCDS CCDS82990.1; -. [P48643-2]; . RefSeq NP_001293084.1; NM_001306155.1. [P48643-2]; . RefSeq NP_036205.1; NM_012073.4. [P48643-1]; . UniGene Hs.1600; -; . UniGene Hs.740762; -; . ProteinModelPortal P48643; -; . BioGrid 116603; 187; . DIP DIP-31181N; -; . IntAct P48643; 122; . MINT MINT-1154718; -; . STRING 9606.ENSP00000280326; -; . iPTMnet P48643; -; . PhosphoSitePlus P48643; -; . SwissPalm P48643; -; . BioMuta CCT5; -; . DMDM 1351211; -; . OGP P48643; -; . REPRODUCTION-2DPAGE IPI00010720; -; . SWISS-2DPAGE P48643; -; . EPD P48643; -; . PaxDb P48643; -; . PeptideAtlas P48643; -; . PRIDE P48643; -; . DNASU 22948; -; . Ensembl ENST00000280326; ENSP00000280326; ENSG00000150753. [P48643-1]; . Ensembl ENST00000506600; ENSP00000423052; ENSG00000150753. [P48643-2]; . GeneID 22948; -; . KEGG hsa:22948; -; . UCSC uc011cmt.3; human. [P48643-1]; . CTD 22948; -; . DisGeNET 22948; -; . GeneCards CCT5; -; . H-InvDB HIX0120997; -; . HGNC HGNC:1618; CCT5; . HPA CAB006271; -; . HPA HPA002238; -; . HPA HPA005958; -; . MalaCards CCT5; -; . MIM 256840; phenotype; . MIM 610150; gene; . neXtProt NX_P48643; -; . OpenTargets ENSG00000150753; -; . Orphanet 139578; Hereditary sensory and autonomic neuropathy with spastic paraplegia; . PharmGKB PA26182; -; . eggNOG KOG0357; Eukaryota; . eggNOG COG0459; LUCA; . GeneTree ENSGT00550000074988; -; . HOGENOM HOG000226735; -; . HOVERGEN HBG106507; -; . InParanoid P48643; -; . KO K09497; -; . OMA IIKDQDK; -; . OrthoDB EOG091G05G4; -; . PhylomeDB P48643; -; . TreeFam TF105638; -; . Reactome R-HSA-389957; Prefoldin mediated transfer of substrate to CCT/TriC; . Reactome R-HSA-389960; Formation of tubulin folding intermediates by CCT/TriC; . Reactome R-HSA-390450; Folding of actin by CCT/TriC; . Reactome R-HSA-390471; Association of TriC/CCT with target proteins during biosynthesis; . Reactome R-HSA-5620922; BBSome-mediated cargo-targeting to cilium; . Reactome R-HSA-6814122; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; . ChiTaRS CCT5; human; . GeneWiki CCT5_(gene); -; . GenomeRNAi 22948; -; . PRO PR:P48643; -; . Proteomes UP000005640; Chromosome 5; . Bgee ENSG00000150753; -; . CleanEx HS_CCT5; -; . ExpressionAtlas P48643; baseline and differential; . Genevisible P48643; HS; . GO GO:0044297; C:cell body; IEA:Ensembl; . GO GO:0005813; C:centrosome; IDA:MGI; . GO GO:0005832; C:chaperonin-containing T-complex; IDA:UniProtKB; . GO GO:0005829; C:cytosol; IDA:HPA; . GO GO:0070062; C:extracellular exosome; IDA:UniProtKB; . GO GO:0005874; C:microtubule; IDA:UniProtKB; . GO GO:0043209; C:myelin sheath; IEA:Ensembl; . GO GO:0005730; C:nucleolus; IDA:HPA; . GO GO:0002199; C:zona pellucida receptor complex; IEA:Ensembl; . GO GO:0005524; F:ATP binding; IEA:UniProtKB-KW; . GO GO:0048487; F:beta-tubulin binding; IPI:UniProtKB; . GO GO:0031681; F:G-protein beta-subunit binding; IPI:UniProtKB; . GO GO:0044183; F:protein binding involved in protein folding; IBA:GO_Central; . GO GO:0051082; F:unfolded protein binding; IBA:GO_Central; . GO GO:0006458; P:'de novo' protein folding; IBA:GO_Central; . GO GO:0007339; P:binding of sperm to zona pellucida; IEA:Ensembl; . GO GO:0061077; P:chaperone-mediated protein folding; IBA:GO_Central; . GO GO:1904851; P:positive regulation of establishment of protein localization to telomere; IMP:BHF-UCL; . GO GO:1904871; P:positive regulation of protein localization to Cajal body; IMP:BHF-UCL; . GO GO:1904874; P:positive regulation of telomerase RNA localization to Cajal body; IMP:BHF-UCL; . GO GO:0032212; P:positive regulation of telomere maintenance via telomerase; IMP:BHF-UCL; . GO GO:0006457; P:protein folding; TAS:Reactome; . GO GO:0050821; P:protein stabilization; IMP:BHF-UCL; . GO GO:0009615; P:response to virus; IEP:UniProtKB; . GO GO:1901998; P:toxin transport; IEA:Ensembl; . CDD cd03339; TCP1_epsilon; 1; . Gene3D 1.10.560.10; -; 2; . Gene3D 3.30.260.10; -; 2; . Gene3D 3.50.7.10; -; 1; . InterPro IPR012718; Chap_CCT_epsi; . InterPro IPR017998; Chaperone_TCP-1; . InterPro IPR002194; Chaperonin_TCP-1_CS; . InterPro IPR002423; Cpn60/TCP-1; . InterPro IPR027409; GroEL-like_apical_dom; . InterPro IPR027413; GROEL-like_equatorial; . InterPro IPR027410; TCP-1-like_intermed; . PANTHER PTHR11353:SF156; PTHR11353:SF156; 1; . Pfam PF00118; Cpn60_TCP1; 1; . PRINTS PR00304; TCOMPLEXTCP1; . SUPFAM SSF52029; SSF52029; 1; . TIGRFAMs TIGR02343; chap_CCT_epsi; 1; . PROSITE PS00750; TCP1_1; 1; . PROSITE PS00751; TCP1_2; 1; . PROSITE PS00995; TCP1_3; 1; .

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